Over 300 civil society groups and religious leaders are said to be taking part along with thousands of South Africans.
The marches have also been endorsed by the Desmond and Leah Tutu Foundation.
Marchers will gather at Burgers Park and will march to the Union Buildings where a list of demands will be handed over to the presidency.
Organisations such as Right to Know (R2K) Campaign, Treatment Action Campaign held pickets this week in support of the march.
The march is expected to begin around midday but those on duty will not be allowed to attend.
