That's according to an analysis of crime trends over the past 20 years released on Wednesday by the SA Institute of Race Relations.
The institute's Frans Cronje says data shows that the Eastern Cape has a murder rate of more than 50 per 100 thousand people, followed closely by the Western Cape while Gauteng is surprisingly the safest province.
"Why exactly that is the case for the Eastern Cape is not something that we have been able to determine. But, on balance it is positioned now on the murder rate, as one of the more dangerous parts of the country," he said.