The demonstrations come after a controversial Cabinet reshuffle and the country's downgrade to junk status.
The Democratic Alliance will march from the Westgate Mall bus rank to Mary Fitzgerald Square in the Johannesburg CBD.
Save South Africa is expected to protest in the Pretoria CBD and other marches have also been planned across the country.
The cold and wet weather hasn’t dampened spirits at Church Square where protesters, who occupied Church Square for about five days, geared up.
About a dozen of the Save SA delegation huddled together under a massive South African flag, which served as their blanket to keep out the cold.
A stage is being setup where some of the leaders are expected to make speeches before marching to the Union Buildings.
The crowds are expected to start gathering from about 10am to depart for the seat of government at about midday.
A white stretch tent has been erected while a handful of Save SA members are listening to struggle songs and dancing.
