The world No. 1 triumphed in Paris last year as part of a run which has seen her win four of the last six grand slams, and despite suffering a shock defeat to Angelique Kerber at the Australian Open she is the strong favorite as the tennis world heads to Roland Garros.
"You do want to play the No. 1 -- you do want to beat them," the 21-time grand slam champion told CNN's Open Court. "I know I did -- but I am ready for that. I am ready for anyone every time."
The 34-year-old appears in good shape ahead of the clay-court showpiece, heading to the French capital following a win over compatriot Madison Keys in the final of last weekend's Rome Masters.
Rome was only Williams' fourth official event of 2016 after she skipped three tournaments because of the flu.
But if she wins at Roland Garros, Williams would tie Steffi Graf's Open Era grand slam record of 22 majors.
"Right now I feel good when my feet first hit the clay," Williams told CNN prior to the Rome tournament. "I always feel amazing because I love the clay.
"The day I lost in Miami (to Svetlana Kuznetsova) -- the next day I was on the clay courts," added Williams. "I didn't take a day off -- I feel good on clay."
