On a night when Wembley paid its respects to the late Dutch legend Johan Cruyff with applause in the 14th minute, a much-changed England side slipped to a rare defeat at the national stadium.
Man-of-the-match Jamie Vardy rounded off a slick passing move to steer in Kyle Walker's cross four minutes before the interval - but Roy Hodgson's side could not protect their lead.
England's defence lived on the edge too often and were eventually punished when a sloppy passage of play led to Danny Rose handling, and Vincent Janssen scored from the spot after 50 minutes.
The big striker was then too strong for substitute Phil Jagielka, although England complained bitterly he had been fouled, before crossing for Luciano Narsingh to score the winner 13 minutes from time.
