Opener Stephen Cook, all-rounder Wayne Parnell and spinner Dane Piedt drop out of the squad that faced New Zealand in the last Test series.
Dean Elgar will captain the side in the warm-up match and will stand in for Du Plessis in the first Test match if the latter is not available for selection as he awaits the birth of his first child.
“Heino Kuhn has shown outstanding form for South Africa A on their recent tour of England which included a double century in the four-day match against Hampshire and a further century against the England Lions.
